Endocrine Abstracts

Introduction: In previous studies, it was noted that increased serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) lead to the increased vertebral fractures risk in patients with acromegaly. This may be explained by the altered quality of bone rather than bone mineral density (BMD) loss. Trabecular bone score (TBS) is an easily available tool to obtain some surrogate information on bone microarchitecture from a routine DXA.Objective: To ev...

Aim: To assess the data of the registry concerning women with acromegaly.Materials and methods: Russian hypothalamic and pituitary tumors registry database, containing the information on 3968 acromegalic patients.Results: From all patients with acromegaly registered in the database, 2878 patients (72.5%) are women. We assessed the following data on gonadal status and reproductive function in this group: 512 patients have irregular ...

Introduction: Epidemiological data for central diabetes insipidus (CDI) are quite sparse.Objectives: To provide an epidemiological data on CDI in different regions of Russia (20 from 83 Federal regions).Materials and methods: We used the Russian Registry for Central Diabetes Insipidus (RCDI) to study the epidemiological features of CDI.Results: A total of 2004 patients with CDI were recorded, 47% women and 59...

BackgroundEctopic ACTH syndrome (EAS) is a rare cause of endogenous hypercortisolism.ObjectiveTo analyze clinical, biochemical features and treatment outcomes of patients with EAS.Materials and methodsRetrospective, observational study on 129 patients (79 women, 50 men) with EAS diagnosed between 1990 and 2020. Plasma levels of ACTH (reference range: morning 7.2&#...

IntroductionThyrotropin-secreting pituitary adenomas (TSH-omas) are rare. For this reason each case of TSH-secreting pituitary tumor can help expand extensive clinical experience in world practice.Materials and methodsWe included 40 patients with TSH secreting pituitary adenomas. Hormonal profile: TSH (0.25-3.5 mIU/L), FT4 (9-20 pmol/l) FT3 (2.5-5.5 pmol/l) were measured by Architect i2000SR (Abbott Laborator...

IntroductionClinically functioning gonadotroph adenomas (FGA) are rare, especially in men. We present a case of a LH/FSH-secreting functioning gonadotroph macroadenoma in an elderly patient, which manifested with visual impairment and was accompanied by secondary erythrocytosis.Clinical caseA 62-y.o. male was admitted to our hospital with a 9-month history of visual impairment and a 5-year history of plethora...

Objective: To develop a non-invasive method of differential diagnosis for ACTH-dependent hypercortisolism using machine learning methods based on clinical data analysis.Materials and methods: This is a single-center study of a retrospective cohort to predict the probability of EAS among patients with ACTH-dependent hypercortisolism using artificial machine learning algorithms. Patients were randomly stratified into 2 samples: training (80%) and test (20%...

Myopathy is a common complication of Cushing’s syndrome (CS), which predicts the possibility of heart muscle damage and may be a cause of heart failure. Goal of this study is to evaluate the prevalence of heart failure in patients with active CS and the probability of recovery after achieving a remission.Materials and methods: We enrolled patients with CS hospitalized in our clinic from October 2018 to December 2022. To confirm the diagnosis of CS w...

Multiple endocrine neoplasia type 1(MEN1) is a hereditary condition caused by mutations in the MEN1 gene, which encodes menin protein. The syndrome predisposes to the development of tumors in both endocrine and non-endocrine systems. In patients with MEN1, pituitary adenomas (PA) occur in approximately 40% of all cases. If patient has MEN1 phenotype with no mutations in MEN1 gene, the condition is regarded as a phenocopy. The reason of several endocrine MEN1-...

Background: Pituitary disease registries are major instruments of epidemiological and clinical data collection used worldwide.Objective: To assess the epidemiological and clinical characteristics of acromegaly in Russia according to Russian hypothalamic and pituitary tumor registryMaterial and methods: Database of the Russian hypothalamic and pituitary tumor registry, which includes data from 84 regions of the country, was used for...